Metamizole

Metamizole
Clinical data
Trade names	Novalgin, others
Anarana hafa	Dipyrone (BAN UK, USAN US)
AHFS/Drugs.com	International Drug Names
Pregnancy; category	Not assigned; no evidence of teratogenicity in animals, use in 3rd trimester may cause heart problems;
Routes of; administration	By mouth, IM, IV, rectal
Sata ara-dalàna
Sata ara-dalàna	Over-the-counter (some countries); prescription-only (others); withdrawn (others);
Pharmacokinetic data
Bioavailability	100% (active metabolites)
Protein binding	48–58% (active metabolites)
Metabolism	Liver
Elimination half-life	14 minutes (parent compound; parenteral); metabolites: 2–4 hours
Excretion	Urine (96%, IV; 85%, oral), faeces (4%, IV).
Identifiers
	IUPAC name [(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino] methanesulfonic acid ;
Angon-drakitra simika sy ara-batana
Raikipohy	C13H17N3O4S
Molar mass	31136 g·mol−1
Modely 3D (JSmol)	Interactive image;
	SMILES c1ccccc1N2N(C)C(C)=C(C2=O)N(C)CS(=O)(=O)O ;
	InChI InChI=1S/C13H17N3O4S/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11/h4-8H,9H2,1-3H3,(H,18,19,20) ; Key:LVWZTYCIRDMTEY-UHFFFAOYSA-N ;
	(what is this?) (verify)

Ny Metamizole, fantatra ihany koa amin'ny hoe dipyrone, dia fanafody fanaintainana, fanamaivanana ny fihenjanana, ary mampidina tazo . Azo ampiasaina izy io rehefa tsy mandaitra ny fanafody hafa.^[4] Haingana ny fiatombohan'ny aretina ary maharitra hatramin'ny 8 ora ny vokany.^[5] Azo omena am-bava, amin'ny lava-pitombenana, na amin'ny tsindrona izy io.^[4]

Anisan'ny voka-dratsiny mahazatra ny fahatsapana rendremana, ny tsy fahazoana aina ao an-kibo, ary ny maloiloy. Anisan'ny voka-dratsiny lehibe ny fihetseham-po mahazaka, anisan'izany ny anafilaksia, ary ny fihenan'ny sela fotsy ao amin'ny ra.^[6] Na dia toa azo antoka aza izany amin'ny fiandohan'ny fitondrana vohoka, dia misy ihany ny ahiahy amin'ny fitondrana vohoka any aoriana. Tsy mety ho an'nymampinono.^[4] Ao amin'ny fianakaviana fanafody ampirone izy io. Tsy opioid izy io; na dia tsy mitovy aza ny loharanom-baovao momba ny maha-NSAID azy.^[7]^[5]

Nahazo patanty ny Metamizole tamin'ny 1922 ary nampiasaina voalohany tamin'ny fitsaboana tany Alemaina.^[8] Amidy amin'ny anarana ara-barotra samihafa izy io. Nesorina tsy ho eny an-tsena intsony izy io tany amin'ny firenena maro, anisan'izany i Etazonia sy Royaume-Uni, tamin'ny taona 1960 sy 70 noho ny voka-dratsiny.^[9] Na dia mbola misy any amin'ny faritra sasany any Eoropa sy any amin'ny firenena an-dalam-pandrosoana aza izy io hatramin'ny taona 2019.

References

↑ Brune, K (1997). "The early history of non-opioid analgesics". Acute Pain 1: 33–40. doi:10.1016/S1366-0071(97)80033-2.
1 2 3 "Fachinformation (Zusammenfassung der Merkmale des Arzneimittels) Novaminsulfon injekt 1000 mg Lichtenstein Novaminsulfon injekt 2500 mg Lichtenstein" (PDF). Winthrop Arzneimittel GmbH (in German). Zinteva Pharm GmbH. February 2013. Archived (PDF) from the original on 16 October 2018. Retrieved 19 April 2014.{{cite web}}: CS1 maint: unrecognized language (link) Endrika:Webarchive
1 2 3 4 "[Drugs for postoperative analgesia: routine and new aspects. Part 1: non-opioids]" (in German). Der Anaesthesist 57 (4): 382–90. April 2008. doi:10.1007/s00101-008-1326-x. PMID 18351305.
1 2 3 "Metamizole containing medicinal products". https://www.ema.europa.eu. Archived from the original on 4 March 2021. Retrieved 16 July 2021. {{cite web}}: External link in |website= (help) Endrika:Webarchive
1 2 Nikolova, Irina; Tencheva, Jasmina; Voinikov, Julian; Petkova, Valentina; Benbasat, Niko; Danchev, Nikolai (January 2012). "Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part I: Pharmaceutical and Nonclinical Profile". Biotechnology & Biotechnological Equipment 26 (6): 3329–3337. doi:10.5504/BBEQ.2012.0089.
↑ Lutz, Mathias (November 2019). "Metamizole (Dipyrone) and the Liver: A Review of the Literature". The Journal of Clinical Pharmacology 59 (11): 1433–1442. doi:10.1002/jcph.1512. PMID 31433499.
↑ Jasiecka, A; Maślanka, T; Jaroszewski, JJ (2014). "Pharmacological characteristics of metamizole.". Polish journal of veterinary sciences 17 (1): 207-14. doi:10.2478/pjvs-2014-0030. PMID 24724493.
↑ Fischer, Jnos (2006). Analogue-based Drug Discovery (in en). John Wiley & Sons.
↑ (22 December 2009) Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs (in en). Elsevier. Endrika:Webarchive

[Brune-1] Brune, K (1997). "The early history of non-opioid analgesics". Acute Pain 1: 33–40. doi:10.1016/S1366-0071(97)80033-2.

[SPC-2] 1 2 3 "Fachinformation (Zusammenfassung der Merkmale des Arzneimittels) Novaminsulfon injekt 1000 mg Lichtenstein Novaminsulfon injekt 2500 mg Lichtenstein" (PDF). Winthrop Arzneimittel GmbH (in German). Zinteva Pharm GmbH. February 2013. Archived (PDF) from the original on 16 October 2018. Retrieved 19 April 2014.{{cite web}}: CS1 maint: unrecognized language (link) Endrika:Webarchive

[deranaes2008-3] 1 2 3 4 "[Drugs for postoperative analgesia: routine and new aspects. Part 1: non-opioids]" (in German). Der Anaesthesist 57 (4): 382–90. April 2008. doi:10.1007/s00101-008-1326-x. PMID 18351305.

[EU2021-4] 1 2 3 "Metamizole containing medicinal products". https://www.ema.europa.eu. Archived from the original on 4 March 2021. Retrieved 16 July 2021. {{cite web}}: External link in |website= (help) Endrika:Webarchive

[Nik2012-5] 1 2 Nikolova, Irina; Tencheva, Jasmina; Voinikov, Julian; Petkova, Valentina; Benbasat, Niko; Danchev, Nikolai (January 2012). "Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part I: Pharmaceutical and Nonclinical Profile". Biotechnology & Biotechnological Equipment 26 (6): 3329–3337. doi:10.5504/BBEQ.2012.0089.

[JCP2019-6] Lutz, Mathias (November 2019). "Metamizole (Dipyrone) and the Liver: A Review of the Literature". The Journal of Clinical Pharmacology 59 (11): 1433–1442. doi:10.1002/jcph.1512. PMID 31433499.

[Jas2014-7] Jasiecka, A; Maślanka, T; Jaroszewski, JJ (2014). "Pharmacological characteristics of metamizole.". Polish journal of veterinary sciences 17 (1): 207-14. doi:10.2478/pjvs-2014-0030. PMID 24724493.

[Fis2006-8] Fischer, Jnos (2006). Analogue-based Drug Discovery (in en). John Wiley & Sons.

[Aron2009-9] (22 December 2009) Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs (in en). Elsevier. Endrika:Webarchive

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