Celecoxib

Celecoxib
Clinical data
Pronunciation	Endrika:IPAc-en SEL-i-KOK-sib
Trade names	Celebrex, Onsenal, Elyxyb, others
AHFS/Drugs.com	Monograph
MedlinePlus	a699022
[[Regulation of therapeutic goods \|Endrika:Engvar data]]	US DailyMed: Celecoxib; US FDA: Celebrex;
Pregnancy; category	AU: B3;
Routes of; administration	By mouth
Drug class	NSAID (COX-2 inhibitor)
Sata ara-dalàna
Sata ara-dalàna	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	Unknown
Protein binding	97% (mainly to serum albumin)
Metabolism	Liver (mainly CYP2C9)
Elimination half-life	7.8 hours; 11 hours (mild hepatic impairment); 13 hours (moderate-severe hepatic impairment)
Excretion	Faeces (57%), urine (27%)
Identifiers
	IUPAC name 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide ;
CompTox Dashboard (EPA)	DTXSID0022777Erreur de script : le module a renvoyé une valeur de type nil. Il est supposé renvoyer un tableau d’exportations.;
ECHA InfoCard	100.211.644Erreur de script : le module a renvoyé une valeur de type nil. Il est supposé renvoyer un tableau d’exportations.
Angon-drakitra simika sy ara-batana
Raikipohy	C17H14F3N3O2S
Molar mass	381.373 g·mol−1
Modely 3D (JSmol)	Interactive image;
	SMILES O=S(=O)(c3ccc(n1nc(cc1c2ccc(cc2)C)C(F)(F)F)cc3)N ;
	InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) ; Key:RZEKVGVHFLEQIL-UHFFFAOYSA-N ;
	(verify)

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Ny Celecoxib, amidy amin'ny anarana marika Celebrex ankoatra ny hafa, dia fanafody manakana ny COX-2 ary fanafody tsy steroidal anti-inflammatoire (NSAID).^[2] Ampiasaina hitsaboana ny fanaintainana sy ny fivontosana amin'ny osteoarthritis, fanaintainana mafy amin'ny olon-dehibe, rheumatoid arthritis, ankylosing spondylitis, fanaintainana mandritra ny fadimbolana, ary rheumatoid arthritis ho an'ny tanora izy io.^[2] Azo ampiasaina ihany koa izy io mba hampihenana ny mety hisian'ny adenoma colorectal amin'ny olona manana polyposis adenomatous familial.^[2] Atelina izy io.^[2] Matetika hita ao anatin'ny adiny iray ny tombontsoa azo.^[2]

Anisan'ny voka-dratsiny mahazatra ny fanaintainan'ny kibo, ny maloiloy ary ny aretim-pivalanana.^[2] Mety ho anisan'ny voka-dratsy lehibe ny aretim-po, fahatapahan'ny lalan-dra, lavaka ao amin'ny tsinay, rà mandriaka ao amin'ny tsinay, tsy fahombiazan'ny voa, ary anafilaksia.^[5]^[2] Tsy soso-kevitra ny hampiasana azy ho an'ireo olona atahorana ho voan'ny aretim-po.^[6]^[7] Mitovy amin'ny NSAID hafa ny loza mety hitranga, toy ny ibuprofen sy naproxen . Tsy soso-kevitra ny hampiasana azy amin'ny faramparan'ny fitondrana vohoka na mandritra ny fampinonoana.^[2]

Nahazo patanty ny Celecoxib tamin'ny 1993 ary nanomboka nampiasaina ara-pitsaboana tamin'ny 1999.^[8] Azo alaina amin'ny endrika fanafody tsy misy fangarony izy io.^[9] Latsaky ny £2 ny vidin'ny famatsiana iray volana any Royaume-Uni ho an'ny NHS tamin'ny taona 2019.^[9] Any Etazonia, ny vidin'ny ambongadiny amin'ity vola ity dia eo amin'ny $US12.90 eo ho eo.^[10] Tamin'ny taona 2011, iray amin'ireo fanafody be mpividy indrindra avy amin'ny Pfizer izy io, miaraka amin'ny varotra 2.5 lavitrisa dolara. Tamin'ny taona 2017, io no fanafody faha-106 be mpampiasa indrindra any Etazonia, miaraka amin'ny fanafody mihoatra ny fito tapitrisa.^[11]^[12]

References

↑ "Celecoxib (Celebrex) Use During Pregnancy". Drugs.com. 4 May 2020. Archived from the original on 25 January 2021. Retrieved 5 May 2020.
1 2 3 4 5 6 7 8 9 "Celecoxib Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. 11 November 2019. Archived from the original on 20 May 2019. Retrieved 5 May 2020.
↑ "Celebrex 100mg capsule - Summary of Product Characteristics (SmPC)". (emc). 13 January 2020. Archived from the original on 6 August 2020. Retrieved 5 May 2020.
1 2 3 4 5 "Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis". Drugs 71 (18): 2457–89. December 2011. doi:10.2165/11208240-000000000-00000. PMID 22141388.
↑ "Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials". Lancet 382 (9894): 769–79. August 2013. doi:10.1016/S0140-6736(13)60900-9. PMC 3778977. PMID 23726390. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3778977.
↑ "Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association". Circulation 115 (12): 1634–42. March 2007. doi:10.1161/circulationaha.106.181424. PMID 17325246.
↑ "Should you still take Celebrex?". Consumer Reports. August 2009. Archived from the original on 18 December 2015. Retrieved 27 December 2015.
↑ Fischer, Jnos (2006). Analogue-based Drug Discovery (in en). John Wiley & Sons.
1 2 (2018) British national formulary : BNF 76, 76, Pharmaceutical Press, 1097–1098.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in Anglisy). Archived from the original on 6 March 2019. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
↑ "Celecoxib - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.

[Drugs.com_pregnancy-1] "Celecoxib (Celebrex) Use During Pregnancy". Drugs.com. 4 May 2020. Archived from the original on 25 January 2021. Retrieved 5 May 2020.

[AHFS2019-2] 1 2 3 4 5 6 7 8 9 "Celecoxib Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. 11 November 2019. Archived from the original on 20 May 2019. Retrieved 5 May 2020.

[3] "Celebrex 100mg capsule - Summary of Product Characteristics (SmPC)". (emc). 13 January 2020. Archived from the original on 6 August 2020. Retrieved 5 May 2020.

[drugs-4] 1 2 3 4 5 "Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis". Drugs 71 (18): 2457–89. December 2011. doi:10.2165/11208240-000000000-00000. PMID 22141388.

[Coxib2013-5] "Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials". Lancet 382 (9894): 769–79. August 2013. doi:10.1016/S0140-6736(13)60900-9. PMC 3778977. PMID 23726390. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3778977.

[AHA2007-6] "Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association". Circulation 115 (12): 1634–42. March 2007. doi:10.1161/circulationaha.106.181424. PMID 17325246.

[Consumer2012-7] "Should you still take Celebrex?". Consumer Reports. August 2009. Archived from the original on 18 December 2015. Retrieved 27 December 2015.

[Fis2006-8] Fischer, Jnos (2006). Analogue-based Drug Discovery (in en). John Wiley & Sons.

[BNF76-9] 1 2 (2018) British national formulary : BNF 76, 76, Pharmaceutical Press, 1097–1098.

[NADAC2019-10] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in Anglisy). Archived from the original on 6 March 2019. Retrieved 3 March 2019.

[ref-11] "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.

[ref1-12] "Celecoxib - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.

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